Biochemistry, University of Washington 1974-1977, Assistant Professor, Pathology and Medicine 1977-82, Associate Professor, 1982-86; Professor, 1986-present; Adjunct Professor, Genome Sciences, 2002-present. Board certification: American Board of Internal Medicine, 1973; American Board of Medical Genetics, Clinical Genetics1984. Helen Hay Whitney Foundation Fellow, 1974-77; Basil O’Connor Fellow, March of Dimes, 1977-1980; Established Investigator, American Heart Association, 1979-1984. Board of Directors, American Society of Human Genetics, 1991-1999 (1994-1999 as Editor); Board of Directors, American Board of Medical Genetics, 1992-1997; President, American Board of Medical Genetics, 1997. Gordon Research Conference on Collagen, Vice-Chair, 2001, Chair 2003. Member, Washington State Board of Health Genetics Task Force 2001-02. Medical Advisory Council, Osteogenesis Imperfecta Foundation, 1990-present, Chair 1990-95; Professional Advisory Board, National Marfan Foundation, 1985-present. Antonin Marfan Award, National Marfan Foundation, 1991. Research Award, Ehlers-Danlos National Foundation, 2002. Memberships: American Society for Clinical Investigation; American Association for the Advancement of Science, Fellow; American Association of Physicians; European Society for Human Genetics; American Society of Investigative Pathology. Editorial Boards: Editor, American Journal of Human Genetics, 1994-1999; Communicating Editor, Human Mutation 1994-present; Editorial Board, Journal of Medical Genetics, 2001-present.

Major research interests: Molecular mechanisms of inherited connective tissue disorders, human mosaicism, outcomes of splice site mutations.