|
Test |
Tumor |
Comment |
Tissue |
| EGFR (EPIDERMAL GROWTH FACTOR
RECEPTOR) |
NON
SMALL CELL LUNG CANCER (NSCLC) |
WHOLE
GENE |
FRESH
TISSUE (ETHANOL-FIXED TISSUE) |
| EGFR (EPIDERMAL GROWTH FACTOR
RECEPTOR) |
NON
SMALL CELL LUNG CANCER (NSCLC) |
EXON
18-21 MUTATIONS (IRESSA/GEFITINIB) RESPONSIVENESS |
FRESH
TISSUE (ETHANOL-FIXED TISSUE) |
|
HER2 /
NEU |
BREAST
CANCER |
OVEREXPRESSION (HERCEPTIN RESPONSIVENESS) |
PARAFFINISED TUMOUR TISSUE |
|
KIT |
GASTROINTESTINAL STROMAL TUMOR, GIST |
MUTATIONS IN EXONS 9, 11, 13 AND 17 (GLEEVEC/IMATINIB
RESPONSIVENESS) |
PARAFFINISED TUMOUR TISSUE |
| ACUTE
MYELOID LEUKEMIA |
MUTATIONS IN EXONS 8, 11 AND 17 (GLEEVEC/IMATINIB
RESPONSIVENESS) |
WHOLE
BLOOD, BONE MARROW ASPIRATE OR PARAFFIN-EMBEDDED BIOPSY |
| MASTOCYTOSIS |
MUTATIONS IN EXON 17 (GLEEVEC/IMATINIB
RESPONSIVENESS) |
PARAFFINISED TUMOUR TISSUE |
| MAST
CELL LEUKEMIA |
MUTATIONS IN EXON 17 (GLEEVEC/IMATINIB
RESPONSIVENESS) |
WHOLE
BLOOD, BONE MARROW ASPIRATE OR PARAFFIN-EMBEDDED BIOPSY |
|
PDGFRA
(PLATELET-DERIVED GROWTH FACTOR RECEPTOR, ALPHA,
PDGFR2) |
GASTROINTESTINAL STROMAL TUMOR, GIST |
MUTATIONS IN EXONS 12 AND 18 (GLEEVEC/IMATINIB
RESPONSIVENESS) |
PARAFFINISED TUMOUR TISSUE |
| FIP1L1 / PDGFRA |
IDIOPATHIC HYPEREOSINOPHILIC SYNDROME |
FUSION
OF FIP1L1 WITH PDGFRA
(GLEEVEC / IMATINIB
RESPONSIVENESS)
|
WHOLE
BLOOD, BONE MARROW ASPIRATE OR PARAFFIN-EMBEDDED BIOPSY |
| FIP1L1 / PDGFRA |
CHRONIC EOSINOPHILIC LEUKEMIA |
FUSION
OF FIP1L1 WITH PDGFRA
(GLEEVEC / IMATINIB
RESPONSIVENESS)
|
WHOLE
BLOOD, BONE MARROW ASPIRATE OR PARAFFIN-EMBEDDED BIOPSY |
|
MSI - MICROSATELLITE
INSTABILITY
|
HEREDITARY NON-POLYPOSIS COLORECTAL CANCER,
HNPCC |
5
MARKERS: BAT25, BAT26, D2S123, D5S346 AND D17S250 |
PARAFFINISED TUMOUR TISSUE AND BLOOD DNA |
|
IMMUNOHISTOCHEMISTRY |
HEREDITARY NON-POLYPOSIS COLORECTAL CANCER,
HNPCC |
ANTIBODIES TO MLH1, MSH2, MSH6 AND PMS2 |
PARAFFINISED TUMOUR TISSUE |
|
KRAS |
VARIOUS TUMORS |
MUTATIONS IN EXONS 1 AND 2 |
PARAFFINISED TUMOUR TISSUE |
|
LOSS OF HETEROZYGOSITY |
ANY TUMOR |
DELETION |
PARAFFINISED TUMOUR TISSUE AND BLOOD
DNA |
